Advances in the Treatment of Neuropathic Pain

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Advances in the Treatment of Neuropathic Pain

Neuropathic pain is the pain that occurs when signal transfer to nerves is not proper. It arises as a direct consequence of a lesion or diseases affecting the somatosensory system. Neuropathic pain is different from the other pain that is due to injury, burn, pressure. Treatment of neuropathic pain includes pharmacological, non-pharmacological and interventional therapies.

From the previous studies, it is concluded that recommended first line pharmacological treatments include antidepressants and anticonvulsants such as gabapentin and pregabalin. However, in some cases, pharmacological therapy alone fails to give adequate control of the chronic pain. Generally, most studies have shown that opioid analgesics (such as morphine) and NSAIDs (such as ibuprofen, Cox-2 inhibitors) are not effective in alleviating most types of neuropathic pain. However, for different patients and different forms of neuropathic pain, these medications may be of value. Relatively high doses of opioids may be required to be effective.

Recent developments include new techniques which have been proven effective on neuropathic pain with therapies like behavioral, cognitive, integrative and physical therapies. Further, many other developments have been made for the treatment of the central neuropathic pain, diabetic peripheral neuropathy, post herpetic neuralgia and cancer pain.

Translational Research in Pain and Itch
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