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A migraine is a painful headache and triptans are available drugs for this acute attack treatment. But because of its vasoconstrictive properties, these drugs are prohibited in patients with vascular conditions. Other limitations of these drugs include side effects like inconsistency in therapeutic action and possible non-responsiveness.

7min read    

Chronic low back pain (cLBP) is considered as one of the most common ailment around the world. It is very challenging to treatment and evaluation successfully in clinical practice and trials. This challenge may be attributed to the use of inadequate outcome parameters.

7min read    

The role of ion channels in pain pathophysiology has elaborated considerably in over the years. The ion channels such as sodium channels (Voltage-gated sodium channels) plays a significant role in action potential activation and proliferation. These action potentials have a high impact upon the ability to react towards a different range of stimuli.

6min read    

One of a convincing meta-analysis explaining that lidocaine-prilocaine cream gives comparable results in reducing pain during perineal repair after vaginal delivery was published in 'The Journal of Maternal-Fetal & Neonatal Medicine'.

Perineal trauma is a common problem that affects women during vaginal delivery which can either be spontaneous (tear) or intentional (episiotomy). Suitable analgesics provide relief when the repair of perineal trauma is required. Amongst these, topical products such as lidocaine-prilocaine cream found effective in relieving pain, but still, there were unanswered questions regarding its efficacy and safety.

9min read    

The analysis of the PRECISION (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen) trial revealed that Celecoxib has a more favourable overall safety profile as compared to naproxen or ibuprofen if administered without aspirin, as per a study issued in 'Journal of the American College of Cardiology'.

8min read    
Key Take-Away:

Chronic pain is the most prevalent cause of functional disability, and has a negative impact on work-related outcomes. One approach that can counter severe chronic pain and help to rehab of subjects on their work is Spinal Cord Stimulation. The following study results affirms that Spinal Cord Stimulation is an effective approach which can make patients with specific chronic pain syndromes to improve work-related outcomes.

Introduction

Chronic pain negatively impacts work-related outcomes, which means that to overcome this burden treatment approaches should be assessed. Spinal cord stimulation (SCS) provides significant relief from pain in specific chronic pain syndromes. This review aimed to recognize and compile evidence on returning to work among patients with chronic pain managed with SCS.

7min read    
Key Take-Away:

Previous studies indicate that patients with ankle sprains can develop osteoarthritis in the future. This study focused on determining the correlation between patient history, physical examination and early osteoarthritis (OA) and estimated that there exists an association between patients physical examination characteristics like pain at the end of plantar flexion, reduced range of motion (ROM) in talocrural joint (TCJ) and talonavicular joint (TNJ), swelling and osteoarthritis.

Introduction:

After an ankle sprain, the structural abnormalities are frequent on MRI. This study determined the association of patient history, physical examination with early osteoarthritis (OA) in patients after an ankle sprain.

7min read    
Key Take-Away:

Median Nerve Neural Mobilization (MNNM) refers to non-invasive physical therapy technique in which pain relief is achieved by mechanical stimulation of the Median Nerve and the brachial plexus. This study relies on approximating effects of MNNM on cervicobrachial pain (CP) as there exists limited data in this context. It was estimated that MNNM technique exhibits superiority over other treatment methods in improving CP.

Introduction:

There is a lack of adequately high-quality randomized controlled clinical studies that estimate the efficacy of neural tissue mobilization approaches such as median nerve neural mobilization (MNNM) and their particular impacts on cervicobrachial pain (CP). This study evaluates the efficacy of MNNM among individuals with CP as compared to the waiting list control group (WLCG).

7min read    
Key Take-Away:

The administration of pre or postoperative medication during dental practices has a great significance to obliterate dental pain. Diclofenac is widely used analgesic, and the study interprets that trans-dermal route of Diclofenac delivery was found to be the safer approach with similar efficacy to that of oral diclofenac in postoperative dental pain.

Introduction:

Examining the safety and effectiveness of oral and transdermal and routes of Diclofenac to manage postoperative pain among individuals going through dental implant placement.

7min read    
Key Take-Away:

A 71-year-old female patient suffered from a chronic migraine for two decades. She never experienced insomnia problems before the first onset of a migraine. A migraine occurred 3-4 times per week, and each episode persisted around 4-8 hours. The pulsating pain was localised at right half of the head. The precipitating factors were the stress, increase in physical activities and sudden cold weather. The relieving factors included warm temperature, slower pacing of life and comfortable environment. The moderate or severe pain intensity was aggravated by or causing avoidance of increased physical activity. The residual symptom between the migraine episodes was the head tense feeling, but not achieving headache severity. The function remained well except avoiding exercise during and between the migraine episodes.

 

After going through the above case presentation, what do you think, could ramelteon alleviate a migraine?

  • Yes
  • No
15min read    
Education
Presentations

Vitamins are organic compounds essential for normal physiological functions.

15 min read    
Education
Presentations

The World Health Organization (WHO) describes the rational use of medicines as, “patients receive medications appropriate to their clinical needs, in doses that meet their own individual requiremen

5 min read    
Education
Smart Guidelines

The guidelines for clinical practice are focused on the preferred approaches to medical problems exhibited by scientifically valid research.

15 min read    
Education
Smart Guidelines

Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses.

American Academy of Otolaryngology-Head and Neck Surgery Foundation
15 min read    
Education
Smart Guidelines

Chronic pain can be a serious consequence of surviving cancer. The prevalence of pain in cancer survivors has been reported to be as high as 40%.

American Society of Clinical Oncology
10 min read    
January 24, 2019

A migraine is a painful headache and triptans are available drugs for this acute attack treatment. But because of its vasoconstrictive properties, these drugs are prohibited in patients with vascular conditions. Other limitations of these drugs include side effects like inconsistency in therapeutic action and possible non-responsiveness.

Key Take-Away:

Chronic pain is the most prevalent cause of functional disability, and has a negative impact on work-related outcomes. One approach that can counter severe chronic pain and help to rehab of subjects on their work is Spinal Cord Stimulation. The following study results affirms that Spinal Cord Stimulation is an effective approach which can make patients with specific chronic pain syndromes to improve work-related outcomes.

Introduction

Chronic pain negatively impacts work-related outcomes, which means that to overcome this burden treatment approaches should be assessed. Spinal cord stimulation (SCS) provides significant relief from pain in specific chronic pain syndromes. This review aimed to recognize and compile evidence on returning to work among patients with chronic pain managed with SCS.

7min read    
Education
Presentations

Vitamins are organic compounds essential for normal physiological functions. However, some of them are not synthesized endogenously by the body and therefore have to be sequestered in small quantities from the diet.

15 min read