Osteoarthritis (OA) is a common joint disease that occurs as a consequence of cartilage degradation and involves a gradual development of pain, stiffness, and loss of motion. The prevalence of OA is 9.6% in men and 18% in women above 60 years having symptomatic OA primarily in knees and hips.

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NSAIDs are the main agents for pain management in patients with osteoarthritis (ОА) and back pain.However, they may cause serious gastrointestinal(GI) and cardiovascular (CV) complications.Prevention of these complications is based on the evaluation of the existing risk factors.

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