Key Take-Away:

Migraine is a chronic, prevalent, and multifactorial neurovascular disorder that leads to severe functional disability. Galcanezumab is an effective medication that can prevent the development of migraine and the study validate the Galcanezumab impact among episodic migraineurs by diagnosing the changes in two disease-specific patient-reported outcomes after 12-week treatment.

Introduction

Headache‐associated functional impairment management is a primary goal for PROs and migraine preventive treatment. Recognizing which medications can enhance patient functioning along with managing migraine headaches is important for reducing the patient burden. This Phase 2b double‐blind, randomized, placebo‐controlled study aimed to assess 12‐week changes in two disease‐specific patient‐reported outcomes (PRO) measures among migraineurs treated with placebo or Galcanezumab.

7min read    

In the present study, a case of a 28-year-old sub-Saharan female is presented with insidious onset of painful burning sensations on the upper trunk, symmetrical numbness and tingling sensation on the hands and feet, progressing over a 5 year period. These symptoms began as intermittent burning sensations on the scapulae and pectoral regions of the upper trunk, which progressed to numbness and paraesthesia of the upper and lower limbs respectively. These were associated with mild weakness of the hands and feet, insomnia, irritability and constipation. There were no urinary symptoms, paralysis, gait disturbances, tremors, jaundice, limb swelling, changes in skin colour, or delusion.

20min read    
Key Take-Away:

A chronic migraine is linked with a significant number of comorbidities. The study results affirm that the effect and rate of this multimorbidity can be a risk factor for migraine chronification and medication overuse headache also hampers its management.

Introduction:

One of the major risk factors for a chronic migraine (CM) management is the multimorbidity as the patients with CM represent a significant number of comorbidities, especially cardiovascular and psychiatric. The study aims to discuss the effect and the frequency of multimorbidity in CM and medication overuse headache (MOH) patients.

6min read    
Key Take-Away:

The ankle sprain is considered as the frequently occurred injuries that lead to chronic ankle instability and impairments like altered balance. The management of such types of sprain can be effectively done using foot orthoses, and this study highlights the performance of new custom-molded foot orthoses with textured surfaces in handling chronic ankle instability.

Introduction:

Chronic ankle instability as a common outcome of ankle sprain leads to numerous impairments such as postural and balance control deficits. Foot orthoses are the frequently used approach for chronic ankle instability recovery. The study directed to estimate the impact of custom-molded foot orthoses with textured surfaces on the chronic ankle instability patients' dynamic balance and to compare their outcomes with different types of foot orthoses.

7min read    
Key Take-Away:

One of the major risk factors of knee OA is obesity, the following study results we found body composition and sarcopenic obesity to be associated with the risk of knee OA.

Introduction
As defined by anthropometric measures, obesity is a well‐recognised risk factor for knee osteoarthritis (OA) however, the information concerning knee OA risk and body composition (fat and muscle mass) is relatively insufficient. The analysis investigated the longitudinal connection of body composition divisions based on muscle mass and fat with knee OA.

6min read