To evaluate the efficacy and safety of mirtazapine in Japanese patients with fibromyalgia (FM), a parallel-group, randomized, double-blind, placebo-controlled phase IIa study was conducted at 57 sites between November 2012 and February 2014.
Mirtazapine is an atypical antidepressant with noradrenergic used to treat depression and other ailments and thus, advised to people experiencing prolonged periods of poor sleep. In this study, the potency of mirtazapine has been deduced proving it to be effective and safe treatment for fibromyalgia. Here the pain score, quality of life of the patient and the adverse events were studied.
The results from the study showed that Sarilumab monotherapy holds superior efficacy and tolerability over Adalimumab monotherapy especially for that rheumatoid arthritis (RA) patients who are unable to continue MTX treatment
For rheumatoid arthritis (RA) patients, biological disease-modifying antirheumatic drugs (bDMARDs) aiming inflammatory cytokines, such as tumor necrosis factor α (TNF-α) or interleukin 6 (IL-6) via the IL-6 receptor (IL-6R), have extended the treatment choices.
The results of the study showed that the stretching exercises were as useful as the Mefenamic acid in treating dysmenorrhea and effect of exercise on relieving menstrual pain increases over time.
The term dysmenorrhea implies to painful cramps and heavy menstrual flow, experienced by most of the women during their menstrual cycle. Pain results in when the uterine pressure produced by the cramps becomes more than 60 mmHg.
This study showed that Capsaicin 8% patch provides modest and statistically significant improvements in pain relief and sleep quality compared with a placebo patch in patients with painful diabetic peripheral neuropathy (PDPN).
A devastating condition that has shown to affect approximately one-quarter of patients with type 2 diabetes mellitus is PDPN. There is lack of data regarding the optimal management of PDPN which has led to variable clinical control with antidepressants, anticonvulsants, or opioid medications. These medications have side effects and are also discontinued due to significant adverse effects, lengthy dose titration, drug-drug interactions, the need for frequent, repeat administration, and the risk of addiction, abuse, and withdrawal symptoms.
In this clinical trial, comparative assessment of clinical efficacy of prednisolone and Ketorolac has been done, and it has been determined that prednisolone proved to be a better treatment option than ketorolac in Post Endodontic Pain (PEP).
Post-endodontic pain mostly arises during the first 2 days after treatment and generally decreases after a few hours.
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