The National Institutes of Health developed the Patient Reported Outcome Measurement Information System (PROMIS) which uses a health domain related to Pain Interference (PI). Matthew J. et al. and his colleagues conducted this research to assess the health domain and its relationship with physical function (as determined by PROMIS Physical Function [PF]). It was administered as a computer adaptive test (CAT), and secondarily its association to a numerical 0 to 10 pain score. The null hypothesis used in statistical theory was PI, measured by CAT. The PI value does not correlate with PF, and therefore no differences were observed between comparisons of PROMIS PF and numerical pain scores.
Venous leg ulcers (VLUs) refers to open lesions that occurs between the knee and ankle joint in the presence of venous disease. The prevalence of chronic venous leg ulcers has increased from 55% to 75% in 10 years. Aragona SE et al. conducted this study to treat chronic vascular lesions according to a cyclic multiphase method. The method follows the instrumental and differential etiologic diagnosis of ulcers of the lower limbs.
Management of persistent low back pain (PLBP) related to high pain-related fear is complex. Caneiro JP et al. conducted this case report to bring insights into the process of change in a person suffering from PLBP and high bending-related fear, who were managed with an individualized behavioural approach of cognitive functional therapy.
There is little information regarding endogenous descending control of itch. In chronic pain, the modulation of lowered conditioned pain reveals a reduction in descending pain inhibition. It has also been indicated that patients with constant irritation also possess reduced endogenous descending inhibition of itch and pain. In this study, Hjalte H. Andersen et al. investigated the level of itch modulation by itch conditioning and pain stimuli.
The sympathetic and parasympathetic systems lead to permanent pupillary fluctuations. These fluctuations are different from pupillary diameter variations (PD) that increases proportionally with pain intensity. The pupillary fluctuations are measured using the variation coefficient of PD (VCPD).
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