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As per a recent study conducted by Zhe Li and colleagues, unilateral percutaneous kyphoplasty (PKP) represents a reliable and safe therapy for osteoporotic vertebral compression fractures (OVCFs) with an intravertebral cleft (IVC). The study involved 309 patients, 266 females and 43 males who obtained PKP treatment from 2010 to 2016. Based on the pre-operative magnetic resonance imaging, the patients were categorized into two groups; OVCFs with IVC and OVCFs without IVC. The posterior wall height (PWH), kyphotic angle (KA) and anterior wall height (AWH) before, after the treatment and at final follow-up were assessed in both groups.

8min read    

A recent trial published in “Lasers in Medical Science” journal enlightens the role of laser irradiation in managing orthodontic pain during fixed appliance treatment if applied immediately. The pain during orthodontic surgeries is intense, especially for 2 to 4 days after fixed appliance treatment. Therefore, Isabela Parsekian Martins and colleagues assessed the effect of low-level laser therapy on dental pain by conducting a randomized, blinded clinical trial.

7min read    

Korean Scientists Bae SC and Lee YH carried out the Bayesian network meta-analysis in which they combined the direct and indirect evidence from various randomized controlled trials (RCTs) examining the safety and efficacy of biosimilar + MTX and infliximab + MTX and placebo + MTX (MTX group) in patients with active RA despite treatment with MTX.

7min read    

As per recent multinational, randomized, double-blind trial published in Mabs Journal, the rituximab (RTX) and its biosimilar CT-P10 appeared to have identical immunogenicity, pharmacodynamics,  safety and efficacy measures in managing rheumatoid arthritis (RA). Park W and colleagues conducted the trial within 372 RA patients, out of which 161 patients allocated to CT-P10 group and 211 to RTX group. The change in primary efficacy endpoint from baseline to week 24 was measured through Disease Activity Score 28 (by using joints-C-reactive protein). The  AUC from time zero to last measurable concentration, from time zero to infinity and maximum level after two infusions were used to measured co-primary pharmacokinetic endpoints. The safety, immunogenicity and pharmacodynamics were also determined.

6min read    

According to a recent meta-analysis, Baricitinib, a JAK 1 and 2 inhibitor has proven to manage rheumatoid arthritis (RA) effectively but with no significant safety concerns. JAK (Janus kinases), play an important role in RA pathogenesis and Baricitinib, therefore, plays a crucial role in RA control. There's no question regarding  Baricitinib efficacy; however comprehensive efficacy evaluation was still to be assessed. 

7min read    
Key Take-Away:

The analysis discovers moderate – quality evidence regarding manipulation and mobilization therapies role in lessening pain and disability with complete safety.

Low back pain is counting among the diseases which cause most devastation in a person's life. About 23% of the population suffering from low back pain. Out of which, 11%–12% population exhibit disability due to severe pain. The management of low back pain involves various modalities; pharmacological as well as non-pharmacological. One section of doctors prefer pharmacological approaches like steroids, NSAIDs, neurotropic, opioid or surgery, While other choose non-pharmacological approaches as these associated with lesser adverse effects. 

Spine J. Author manuscript; available in PMC 2018 Jun 27
26min read    
Key Take-Away:

Both dynamic contrast-enhanced MRI (DCE-MRI) and RA MRI Score (RAMRIS) measures were equally sensitive to treatment effects with Infliximab.

With the technology advancements over the past decade, the treatment options for rheumatoid arthritis (RA) have expanded markedly. However, the acceptable duration for placebo control has also shortened, with rescue therapy typically offered within 14–16 weeks.

PLoS One. 2017 Dec 13; 12(12):e0187397
32min read    
Key Take-Away:

Dexmedetomidine-ketamine combination is a safe alternative for sedation during the cardiac catheterization procedure without the incidence of any hemodynamic or respiratory effects. However, it is associated with some delayed recovery. 

Management of children with congenital heart disease is challenging for anesthesiologists, especially during cardiac catheterization. 

Joshi VS, Kollu SS, Sharma RM. Ann Card Anaesth 2017;20:422-6
18min read    
Key Take-Away:

There is moderate-to high-quality evidence that anticonvulsants are ineffective for the treatment of low back pain or lumbar radicular pain. There is high-quality evidence that gabapentinoids have a higher risk of adverse events.

Globally, millions of people are suffered from low back pain (LBP) and become a major cause of disability than any other health complication. It is predicted that about 5% to 10% of patients with LBP have sciatica and followed by leg pain.

CMAJ. 2018 Jul 3;190(26):E786-93.
18min read    
Key Take-Away:

In patients with gout and major cardiovascular coexisting conditions, febuxostat was non-inferior to allopurinol with respect to rates of adverse cardiovascular events.

Gout is a chronic inflammatory disorder characterised by hyperuricemia, arthropathy, tophus development, and urolithiasis. Gout is reported to be associated with an increased risk of cardiovascular and chronic kidney disease. 

N Engl J Med. 2018 Mar 29;378(13):1200-1210
18min read    
Education

Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses.

American Academy of Otolaryngology-Head and Neck Surgery Foundation
15 min read    
Education

Chronic pain can be a serious consequence of surviving cancer. The prevalence of pain in cancer survivors has been reported to be as high as 40%.

American Society of Clinical Oncology
10 min read    
Education

Neuropathic pain is defined as the pain initiated or caused by a primary lesion, dysfunction, or transitory perturbation of peripheral or central nervous system.

Western Australian Therapeutic Advisory Group
2min read    
Education

Transitional care, as defined by the Society for Adolescent Medicine refers to the purposeful, planned movement of adolescents and young adults with chronic physical and medical conditions from chi

Ann Rheum Dis 2016;0:1–8
4min read    
Education

As per the World Health Organization (WHO), osteoporosis refers to a progressive systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of the bone tissues, w

Arch Osteoporos. 2017; 12(1): 43.
2min read    
July 18, 2018

As per a recent study conducted by Zhe Li and colleagues, unilateral percutaneous kyphoplasty (PKP) represents a reliable and safe therapy for osteoporotic vertebral compression fractures (OVCFs) with an intravertebral cleft (IVC). The study involved 309 patients, 266 females and 43 males who obtained PKP treatment from 2010 to 2016. Based on the pre-operative magnetic resonance imaging, the patients were categorized into two groups; OVCFs with IVC and OVCFs without IVC. The posterior wall height (PWH), kyphotic angle (KA) and anterior wall height (AWH) before, after the treatment and at final follow-up were assessed in both groups.

Key Take-Away:

The analysis discovers moderate – quality evidence regarding manipulation and mobilization therapies role in lessening pain and disability with complete safety.

Low back pain is counting among the diseases which cause most devastation in a person's life. About 23% of the population suffering from low back pain.

Spine J. Author manuscript; available in PMC 2018 Jun 27
26min read    
Education

Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses. Sinusitis is the fifth most common diagnosis in the world; more than 1 in 5 antibiotics prescribed in adults are for sinusitis. Irrespective of the high incidence and economic burden of sinusitis, significant practice dissimilarities exist through and within the numerous disciplines involved in managing the condition. The guideline is applicable for patients aged 18 years and above with a clinical diagnosis of uncomplicated rhinosinusitis.

American Academy of Otolaryngology-Head and Neck Surgery Foundation
15 min read