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Rheumatoid arthritis (RA) is a chronic inflammatory disease marked by focal pathologic bone resorption and caused due to the excessive activity of osteoclasts (OC).

7min read    

Osteoarthritis of the hands occurs as a part of nodal osteoarthritis (a form of osteoarthritis that runs in families). It is more common inn women aged 40 or 50 years, around the menopause. McGee and Mathiowetz performed the study to depict whether a joint-protection strategy changes the mechanics of opening a sealed jar.

7min read    

In the lateral ankle sprain, swelling, tenderness, and ecchymosis don’t correlate with the time to functional recovery. It has been known that psychosocial factors like symptoms of depression and low pain self-efficacy correlate with pain intensity and magnitude of limitations in patients with musculoskeletal problems.

8min read    

The recent study was implemented to find out the short- and long-term effectiveness and safety of the 5% lidocaine medicated plaster in postherpetic neuralgia (PHN) in elderly patients (≥70 years of age).

After stratification according to the age (<70 years and ≥70 years), the data from three European clinical trials were compared. The length of study phase was 4 weeks for study 1, 8 weeks for study 2, and up to 12 months for study 3. Pain intensity, pain relief, allodynia severity, Clinical Global Impression of Change, and Global Patient Impression of Change were the effectiveness outcome measures. The adverse event documentation was used to estimate the safety.

7min read    

Dual-energy computed tomography (CT) can detect tophi in patients with chronic gout. Nevertheless, other information that can be obtained from the same scan was not the focus of the research by  Diekhoff and colleagues, e.g., the detection of bone marrow edema (BME) via virtual bone marrow imaging (VBMI). The study was focused on estimating whether if BME in patients with acute arthritis can be solved with VBMI using magnetic resonance imaging (MRI) as the standard of reference.

7min read    
Key Take-Away:

Second line biologic therapy is preferred for patients suffering from rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). The presented systematic review focuses on anti-tumor necrosis factor (TNF) therapy as criteria to comparatively analyze the efficacy of different second line biologic therapies in the treatment of RA, spondyloarthritis (SpA), and PsA. The severity of psoriasis and the predominance of enthesitis and/or dactylitis may drive the choice toward ustekinumab or secukinumab in PsA, and the latter in AS.

The Italian board for the Tailored Biologic therapy (ITABIO) reviewed the most consistent literature to indicate the best strategy for the second-line biologic choice in patients with RA, SpA, and psoriatic arthritis PsA.

9min read    
Key Take-Away:

Osteoarthritis (OA) of the knee is a common, nonfatal, chronic condition that causes pain and physical disability in older people. Persons with knee OA report difficulty with activities that require ambulation and transfer from sitting to standing position. Exercise interventions, especially muscle strengthening therapies can potentially benefit the patients suffering from acute pain and instability associated with osteoarthritis (OA). The present systematic review assessed if the increase of 30% in knee strength is associated with the improvement in illness and disability in OA patients.

To analyze if exercise interventions for patients with knee osteoarthritis (OA) following the American College of Sports Medicine (ACSM) definition of muscle strength training differs from other types of exercise, and to analyze associations between changes in muscle strength, pain, and disability.

8min read    
Key Take-Away:

Tocilizumab is a humanized anti-IL-6 receptor monoclonal antibody used for the treatment of severe to moderate rheumatoid arthritis. Tocilizumab (TCZ) can improve the patient and physician measures of disease activity and it remains unaffected by the serological status of rheumatoid arthritis (RA) patient.

Tocilizumab is a humanized anti-IL-6 receptor monoclonal antibody used for the treatment of severe to moderate rheumatoid arthritis.

7min read    
Key Take-Away:

Breast cancer treatment often leads to neuropathic pain which results in deterioration of the sleep quality; however, evidences for this finding are not fully discovered. The study presented here is based on the understanding of sleep impairment associated with neuropathic pain occurring in the first year after the diagnosis of breast cancer.

Data regarding the impact of breast cancer treatment-related neuropathic pain (NP) on sleep quality are scarce.

7min read    
Key Take-Away:

Sevoflurane is a potential anesthetic used in pediatric patients, but its administration can lead to agitation in children. However, this agitation can be minimized with the help of medications. 

Sevoflurane is often used in pediatric anesthesia and is associated with high incidence of psychomotor agitation.

8min read    
Education

This guideline replaces the earlier CG88 i.e. Early management of persistent non-specific low back pain.

NICE
10 min read    
Education

Fibromyalgia syndrome is a common disorder characterized by multiple tender points, widespread deep muscle pain, sleep disturbance, fatigue and depression.

14min read    
Education

Gout involves problem with the purine metabolism. In this disease, the uric acid levels are increased (hyperuricemia) and urate crystals accumulates in joints and tissues of the body.

NICE
6 min read    
Education

Syndesmotic injuries at the ankle joint are injuries to the ligaments that connect the tibia and fibula.

NICE
10 min read    
Education

Fibromyalgia is a syndrome which is indicated by chronic widespread pain.

ACSAP
10 min read    
December 2, 2017

Rheumatoid arthritis (RA) is a chronic inflammatory disease marked by focal pathologic bone resorption and caused due to the excessive activity of osteoclasts (OC).

Key Take-Away:

Second line biologic therapy is preferred for patients suffering from rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). The presented systematic review focuses on anti-tumor necrosis factor (TNF) therapy as criteria to comparatively analyze the efficacy of different second line biologic therapies in the treatment of RA, spondyloarthritis (SpA), and PsA. The severity of psoriasis and the predominance of enthesitis and/or dactylitis may drive the choice toward ustekinumab or secukinumab in PsA, and the latter in AS.

The Italian board for the Tailored Biologic therapy (ITABIO) reviewed the most consistent literature to indicate the best strategy for the second-line biologic choice in patients with RA, SpA, and

9min read    
Education

This guideline replaces the earlier CG88 i.e. Early management of persistent non-specific low back pain. Here, low back pain and sciatica has been estimated and managed in people aged 16 and over alongwith the physical, psychological, pharmacological and surgical treatments for the same. It is pivoted to improve people's quality of life, encouraging the most effective forms of care for low back pain and sciatica.

NICE
10 min read