Evaluation of cardiovascular depression effect for propofol during anaesthesia induction period on morbidly obese patients

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Evaluation of cardiovascular depression effect for propofol during anaesthesia induction period on morbidly obese patients

Recently the Chinese Scientists undertook a study aimed to determine the pharmacodynamic (PD) effects of propofol during anaesthesia induction period on morbidly obese (MO) patients. The PD effects were measured by cardiovascular depression in MO patients by evaluating four major hemodynamic indexes, i.e., three indexes about blood pressure and cardiac output (CO).

Pharmacokinetic/pharmacodynamic (PK/PD) modelling based on population analysis was carried out. Two propofol dosing scalars based on total body weight (TBW) or lean body weight (LBW), were used for MO subjects.

Within 1 minute after intravenous injection of propofol (2 mg/kg), the blood pressure and CO of the subjects rapidly decreased.

At and 1 minute after propofol administration, the TBW group showed significantly lower blood pressure and CO values when compared with the control group, whereas the LBW group and control group had similar PD profile.

Moreover, the EC50 of propofol got significantly decreased in MO patients, but the other PD parameters were similar among control and MO subjects. The change in PD parameters indicates that propofol potency and sensitivity was increased in MO subjects.

In MO patients the propofol dosing on LBW would be a safer choice than TBW due to less cardiovascular depression effect.

Source

Biomed Pharmacotherapy

The source:

https://www.ncbi.nlm.nih.gov/pubmed/29990851

Original title of article:

Characterization of cardiovascular depression effect for propofol during anaesthesia induction period on morbidly obese patients.

Authors:

Wu Z, Li J et al.

SearchTags: 
Diagnostic, Propofol, Anaesthesia

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