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Recently, the secondary analysis of a randomized controlled trial was conducted to explore the role of inflammation in long-term recovery after Total Knee Arthroplasty (TKA). A secondary analysis of a randomized controlled trial of physical rehabilitation ± progressive strength training (PST) was done.

7min read    

Ultrasound (US) findings in gout patients showed sensitivity to change and concurrent validation with a uric acid reduction after urate-lowering therapy (ULT) in gout patients. Recently, a study was performed to evaluate the effect of ULT on gout US lesions and review sensitivity of US to changes in gout patients.

7min read    

A recent pairwise meta-analysis and network meta-analysis examined the relative efficacy, safety, and tolerability of prophylactic medications in the management of migraine.

6min read    

Clinical practice guidelines can improve the process and outcomes of patient care in low back pain (LBP) and need for better adherence to an LBP guideline. To manage nonspecific LBP in routine physical therapy practice, the American Physical Therapy Association (APTA) elaborated on strategies with regards to evidence-based practice guideline for LBP. This guideline describes an association of LBP with mobility deficit, leg pain and a directional preference, coordination impairment (lumbar instability) and fear-avoidance behavior.

9min read    

Most of the patients, who underwent surgery, experience the postoperative pain. However, less than a half of patients get adequate relief from this pain. Therefore, an efficient postoperative pain control management is required for the care of the surgical patients. Many of postoperative interventions and strategies are there to tackle this problem, but their efficacy is still uncertain.

8min read    
Key Take-Away:

Mirtazapine is an atypical antidepressant with noradrenergic used to treat depression and other ailments and thus, advised to people experiencing prolonged periods of poor sleep. In this study, the potency of mirtazapine has been deduced proving it to be effective and safe treatment for fibromyalgia. Here the pain score, quality of life of the patient and the adverse events were studied.

To evaluate the efficacy and safety of mirtazapine in Japanese patients with fibromyalgia (FM), a parallel-group, randomized, double-blind, placebo-controlled phase IIa study was conducted at 57 sites between November 2012 and February 2014.

8min read    
Key Take-Away:

The results from the study showed that Sarilumab monotherapy holds superior efficacy and tolerability over Adalimumab monotherapy especially for that rheumatoid arthritis (RA) patients who are unable to continue MTX treatment

For rheumatoid arthritis (RA) patients, biological disease-modifying antirheumatic drugs (bDMARDs) aiming inflammatory cytokines, such as tumor necrosis factor α (TNF-α) or interleukin 6 (IL-6) via the IL-6 receptor (IL-6R), have extended the treatment choices.

Burmester GR, et al. Ann Rheum Dis 2016;0:1–8.
17min read    
Key Take-Away:

The results of the study showed that the stretching exercises were as useful as the Mefenamic acid in treating dysmenorrhea and effect of exercise on relieving menstrual pain increases over time.

The term dysmenorrhea implies to painful cramps and heavy menstrual flow, experienced by most of the women during their menstrual cycle. Pain results in when the uterine pressure produced by the cramps becomes more than 60 mmHg.

Oman Medical Journal [2017], Vol. 32, No. 1: 47–53
14min read    
Key Take-Away:

This study showed that Capsaicin 8% patch provides modest and statistically significant improvements in pain relief and sleep quality compared with a placebo patch in patients with painful diabetic peripheral neuropathy (PDPN). 

A devastating condition that has shown to affect approximately one-quarter of patients with type 2 diabetes mellitus is PDPN. There is lack of data regarding the optimal management of PDPN which has led to variable clinical control with antidepressants, anticonvulsants, or opioid medications. These medications have side effects and are also discontinued due to significant adverse effects, lengthy dose titration, drug-drug interactions, the need for frequent, repeat administration, and the risk of addiction, abuse, and withdrawal symptoms. 

The Journal of Pain, Vol 18, No 1 (January), 2017: pp 42-53
21min read    
Key Take-Away:

In this clinical trial, comparative assessment of clinical efficacy of prednisolone and Ketorolac has been done, and it has been determined that prednisolone proved to be a better treatment option than ketorolac in Post Endodontic Pain (PEP).

Post-endodontic pain mostly arises during the first 2 days after treatment and generally decreases after a few hours. 

8min read    
Education

Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses.

American Academy of Otolaryngology-Head and Neck Surgery Foundation
15 min read    
Education

Chronic pain can be a serious consequence of surviving cancer. The prevalence of pain in cancer survivors has been reported to be as high as 40%.

American Society of Clinical Oncology
10 min read    
Education

Neuropathic pain is defined as the pain initiated or caused by a primary lesion, dysfunction, or transitory perturbation of peripheral or central nervous system.

Western Australian Therapeutic Advisory Group
2min read    
Education

Transitional care, as defined by the Society for Adolescent Medicine refers to the purposeful, planned movement of adolescents and young adults with chronic physical and medical conditions from chi

Ann Rheum Dis 2016;0:1–8
4min read    
Education

As per the World Health Organization (WHO), osteoporosis refers to a progressive systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of the bone tissues, w

Arch Osteoporos. 2017; 12(1): 43.
2min read    
February 21, 2018

Recently, the secondary analysis of a randomized controlled trial was conducted to explore the role of inflammation in long-term recovery after Total Knee Arthroplasty (TKA). A secondary analysis of a randomized controlled trial of physical rehabilitation ± progressive strength training (PST) was done.

Key Take-Away:

Mirtazapine is an atypical antidepressant with noradrenergic used to treat depression and other ailments and thus, advised to people experiencing prolonged periods of poor sleep. In this study, the potency of mirtazapine has been deduced proving it to be effective and safe treatment for fibromyalgia. Here the pain score, quality of life of the patient and the adverse events were studied.

To evaluate the efficacy and safety of mirtazapine in Japanese patients with fibromyalgia (FM), a parallel-group, randomized, double-blind, placebo-controlled phase IIa study was conducted at 57 si

8min read    
Education

Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses. Sinusitis is the fifth most common diagnosis in the world; more than 1 in 5 antibiotics prescribed in adults are for sinusitis. Irrespective of the high incidence and economic burden of sinusitis, significant practice dissimilarities exist through and within the numerous disciplines involved in managing the condition. The guideline is applicable for patients aged 18 years and above with a clinical diagnosis of uncomplicated rhinosinusitis.

American Academy of Otolaryngology-Head and Neck Surgery Foundation
15 min read